Structural Requirements for α-Latrotoxin Binding and α-Latrotoxin-stimulated Secretion
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چکیده
منابع مشابه
Neurexins Are Functional α-Latrotoxin Receptors
receptor for ␣-latrotoxin and that neurexin 1␣ is not a functional receptor (Lelianova et al., 1997). However, the Southwestern Medical Center Dallas, Texas 75235 Ca 2ϩ independence of ␣-latrotoxin action is controversial , and the possible function of neurexins as ␣-latro-toxin receptors has not been tested directly. Studies of neurexin 1␣ knockout mice demonstrated that ␣-latro-Summary toxin ...
متن کاملα-Latrotoxin Stimulates Exocytosis by the Interaction with a Neuronal G-Protein-Coupled Receptor
alpha-Latrotoxin is a potent stimulator of neurosecretion. Its action requires extracellular binding to high affinity presynaptic receptors. Neurexin I alpha was previously described as a high affinity alpha-latrotoxin receptor that binds the toxin only in the presence of calcium ions. Therefore, the interaction of alpha-latrotoxin with neurexin I alpha cannot explain how alpha-latrotoxin stimu...
متن کاملMolecular Evolution of α-Latrotoxin, the Exceptionally Potent Vertebrate Neurotoxin in Black Widow Spider Venom
Black widow spiders (members of the genus Latrodectus) are widely feared because of their potent neurotoxic venom. α-Latrotoxin is the vertebrate-specific toxin responsible for the dramatic effects of black widow envenomation. The evolution of this toxin is enigmatic because only two α-latrotoxin sequences are known. In this study, ~4 kb α-latrotoxin sequences and their homologs were characteri...
متن کاملThe PLAT domain: a new piece in the PKD1 puzzle
Südhof TC: α α-Latrotoxin receptor CIRL/latrophilin 1 (CL1) defines an unusual family of ubiquitous G-protein-linked receptors. requirements for α α-latrotoxin binding and α α-latrotoxin-stimulated secretion. α α-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor. AG: A novel ubiquitously expressed α α-latrotoxin receptor is a member of the CIRL famil...
متن کاملalpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins.
alpha-Latrotoxin, a potent neurotoxin from black widow spider venom, triggers synaptic vesicle exocytosis from presynaptic nerve terminals. alpha-Latrotoxin is a large protein toxin (120 kDa) that contains 22 ankyrin repeats. In stimulating exocytosis, alpha-latrotoxin binds to two distinct families of neuronal cell-surface receptors, neurexins and CLs (Cirl/latrophilins), which probably have a...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1999
ISSN: 0021-9258
DOI: 10.1074/jbc.274.6.3590